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The FAP regimen was modified and low-dose consecutive daily administration of cisplatin (CDDP) and continuous infusion of 5-fluorouracil (5-FU) and pirarubicin were employed to reduce the toxicity and achieve synergy. Patients with advanced and recurrent gastric cancer were treated with this regimen as early phase II trial and its efficacy and toxicity were assessed.

Phase II Study of 5-Fluorouracil, Pirarubicin and Low-dose Consecutive Administration of Cisplatin for Advanced and Recurrent Gastric Cancer