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The p53 mutation spectrum of prostate cancers developing in Japan indicates a role for environmental factors. This suggests there might be differences in susceptibility due to genetic polymorphisms in metabolic activation enzyme genes. We analyzed genetic polymorphisms of the xenobiotic-metabolizing enzymes, CYP1A1 and GSTM1.

Cytochrome P4501A1 and Glutathione S-Transferase M1 Genotypes as Risk Factors for Prostate Cancer in Japan