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Cultured epithelial autografts (CEA) have been clinically utilized since 1981 &amp; can be a lifesaving procedure in patients with extensive full thickness burns. CEA is more susceptible to bacterial contamination &amp; complete graft loss than traditional split-thickness autografts, yet no standard of practice exists for the postoperative care of these grafts to minimize infection &amp; maximize graft take. Prior to 2019, care of CEA patients at our institution was not standardized &amp; instead varied upon the attending surgeon’s practice. With the input of interdisciplinary team members, CEA patient care was standardized via phase-based guidelines (PBGs), leading to improved team communication &amp; improved patient outcomes. Methods PBGs were created via interdisciplinary collaboration among surgeons, APCs, nursing staff, PT/OT, &amp; psychosocial providers. Team members agreed upon 3 facets of patient care: Wound Care/Airing Out, Restrictions/Visitors, &amp; Burn Therapy (Figure 1). As wounds progressed postoperatively, patient phases were advanced, liberalizing them from rigorous infection-prevention techniques to strict unit standards for non-CEA burn patients. In 2019, the utilization of patient-specific CEA care plans ceased in favor of standardized PBGs. A retrospective chart review was conducted on all patients from 2018-2021 who received CEA &amp; survived their injuries. Some patients underwent a single CEA application while others underwent multiple operations. CEA graft take was assessed on all wounds from each surgery. Results CEA was rarely used at our institution. Beginning in 2018, seven patients received CEA &amp; survived their injuries, ranging in age from 4-59 yrs (mean 24) &amp; %TBSA from 38-80 (mean 53) (Table 1). Implementation of PBGs correlated with subjective improvement in team communication &amp; increased mean percentages of CEA graft take from &amp;lt; 35% to &amp;gt;75%. Conclusions PBGs have standardized care for our CEA patients, eliminated communication errors among team members, &amp; increased CEA graft take. Further research is needed to determine efficacy in decreasing infection, antibiotic use, hospital stay length, &amp; mortality in these patients.

608 Utilization of Phase-Based Guidelines For Patient Care After Application of Cultured Epithelial Autograft