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Column liquid chromatography (LC) and thin-layer chromatography (TLC)densitometry methods are described for simultaneous determination of acediasulfone (Ace) and cinchocaine (Cinco). In the LC method, the separation and quantitation of the 2 drugs was achieved on a Zorbax C8 column (5 μm, 150 × 4.6 mm id) using a mobile phase composed of methanol-phosphate buffer, pH 2.5 (66 + 34, v/v), at a flow rate of 1 mL/min and ultraviolet detection at 300 and 327 nm for Ace and Cinco, respectively. The method showed linearity over concentration ranges of 20-200 and 45685 μg/mL, respectively. In the TLCdensitometry method, a mobile phase composed of methanol-tetrahydrofuran-acetic acid (45 + 5 + 0.5, v/v/v) was used for the separation of the 2 drugs. The linearity range was 0.5-4 and 2-9 μg/spot, respectively. In addition, stability indicating TLCdensitometry method has been developed for determination of cefuroxime sodium in the presence of 570% of its known hydrolytic degradation products. The mobile phase butanol-methanol-tetrahydrofuran-concentrated ammonium hydroxide (50 + 50 + 50 + 5, v/v/v/v) was used. The concentration range was 210 g/spot. The optimized methods proved to be specific and accurate for the analysis of the cited drugs in laboratory-prepared mixtures and dosage forms. The obtained results agreed statistically with those obtained by the reference methods.

journal of aoac international

Column and Thin-Layer Chromatographic Methods for the Simultaneous Determination of Acediasulfone in the Presence of Cinchocaine, and Cefuroxime in the Presence of Its Hydrolytic Degradation Products