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Carbapenemase-producing Enterobacterales represent a major therapeutic challenge. MBLs, requiring zinc at their catalytic site, could be inhibited by meso-dimercaptosuccinic acid (DMSA), a heavy metal chelator already widely used for treating lead intoxication.

journal of antimicrobial chemotherapy

Dimercaptosuccinic acid in combination with carbapenems against isogenic strains of <i>Escherichia coli</i> producing or not producing a metallo-β-lactamase <i>in vitro</i> and in murine peritonitis

Dimercaptosuccinic acid in combination with carbapenems against isogenic strains of Escherichia coli producing or not producing a metallo-β-lactamase in vitro and in murine peritonitis