English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  To better understand transmission dynamics, we characterized  Plasmodium falciparum  genetic diversity in Eswatini, where transmission is low and sustained by importation.    Methods  Twenty-six  P. falciparum  microsatellites were genotyped in 66% of confirmed cases (2014–2016; N = 582). Population and within-host diversity were used to characterize differences between imported and locally acquired infections. Logistic regression was used to assess the added value of diversity metrics to classify imported and local infections beyond epidemiology data alone.    Results  Parasite population in Eswatini was highly diverse (expected heterozygosity [H E ] = 0.75) and complex: 67% polyclonal infections, mean multiplicity of infection (MOI) 2.2, and mean within-host infection fixation index (F WS ) 0.84. Imported cases had comparable diversity to local cases but exhibited higher MOI (2.4 vs 2.0;  P  = .004) and lower mean F WS  (0.82 vs 0.85;  P  = .03). Addition of MOI and F WS  to multivariate analyses did not increase discrimination between imported and local infections.    Conclusions  In contrast to the common perception that  P. falciparum  diversity declines with decreasing transmission intensity, Eswatini isolates exhibited high parasite diversity consistent with high rates of malaria importation and limited local transmission. Estimates of malaria transmission intensity from genetic data need to consider the effect of importation, especially as countries near elimination.

High Genetic Diversity of Plasmodium falciparum in the Low-Transmission Setting of the Kingdom of Eswatini