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Co-pathogens that threaten the fetus during gestation, including human cytomegalovirus (HCMV), may contribute to mother-to-child transmission of HIV-1. We show that HCMV infection of placental macrophages may promote HIV replication and transmission as a consequence of inflammation and inhibition of intrinsic antiviral responses.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Human Cytomegalovirus Enhances Placental Susceptibility and Replication of Human Immunodeficiency Virus Type 1 (HIV-1), Which May Facilitate In Utero HIV-1 Transmission