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Lung CD4 + T-cell depletion and dysfunction, CD8 + T-cell alveolitis, smoking, and poor control of human immunodeficiency virus (HIV) are features of HIV-associated chronic obstructive pulmonary disease (COPD), but these changes have not been evaluated in smokers at risk for COPD. We evaluated the impact of viral suppression following initiation of antiretroviral therapy (ART) on HIV-specific immunity and the balance of the CD4 + T-cell to CD8 + T-cell ratio in the lung.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

HIV Suppression Restores the Lung Mucosal CD4<sup>+</sup>T-Cell Viral Immune Response and Resolves CD8<sup>+</sup>T-Cell Alveolitis in Patients at Risk for HIV-Associated Chronic Obstructive Pulmonary Disease

HIV Suppression Restores the Lung Mucosal CD4+T-Cell Viral Immune Response and Resolves CD8+T-Cell Alveolitis in Patients at Risk for HIV-Associated Chronic Obstructive Pulmonary Disease

HIV Suppression Restores the Lung Mucosal CD4⁺T-Cell Viral Immune Response and Resolves CD8⁺T-Cell Alveolitis in Patients at Risk for HIV-Associated Chronic Obstructive Pulmonary Disease