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It is becoming increasingly apparent that certain mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) alter the parasite's susceptibility to diverse compounds. Here we investigated the interaction of PfCRT with 3 tricyclic compounds that have been used to treat malaria (quinacrine [QC] and methylene blue [MB]) or to study P. falciparum (acridine orange [AO]).

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the<i>Plasmodium falciparum</i>Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs

Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via thePlasmodium falciparumChloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs