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[Extract] Animal studies such as published recently in this journal [1] show benefits of antiplatelet agents in experimental models of Staphylococcus aureus infective endocarditis (IE). It is, therefore, important to consider how these experimental data translate into clinical practice. A number of human studies have considered this area, concentrating almost exclusively on long-term aspirin usage. We have performed a meta-analysis of these 9 published studies [2–10] to assess whether the data may provide a basis for future trials and possibly change Infectious Diseases Society of America guidelines that recommend that aspirin should not be used in IE

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

An Association Between Aspirin Use in Human Cases of Infective Endocarditis and Reduced Systemic Embolism Is Shown in Meta-analysis of Observational Studies