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Cytomegalovirus (CMV) infection during fetal life causes severe symptoms and is associated with prolonged viral excretion. Previous studies reported low CD4(+) T-cell responses to CMV infection in early life, contrasting with large responses of effector CD8(+) T cells. The mechanisms underlying the defective CD4(+) T-cell responses and the possible dissociation with CD8(+) T-cell responses have not been clarified.

Functional Exhaustion Limits CD4+and CD8+T-Cell Responses to Congenital Cytomegalovirus Infection

Functional Exhaustion Limits CD4⁺and CD8⁺T-Cell Responses to Congenital Cytomegalovirus Infection