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Mechanisms mediating immunity to malaria remain unclear, but animal data and experimental human vaccination models suggest a critical role for CD4(+) T cells. Advances in multiparametric flow cytometry have revealed that the functional quality of pathogen-specific CD4(+) T cells determines immune protection in many infectious models. Little is known about the functional characteristics of Plasmodium-specific CD4(+) T-cell responses in immune and nonimmune individuals.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Effector Phenotype of<i>Plasmodium falciparum</i>–Specific CD4<sup>+</sup>T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations

Effector Phenotype ofPlasmodium falciparum–Specific CD4+T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations

Effector Phenotype ofPlasmodium falciparum–Specific CD4⁺T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations