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The interplay between Candida species and pattern recognition receptors, interleukins, kynurenine, and T cells has been studied in murine and ex vivo human studies, but data are lacking from patients with invasive fungal infections. Interleukin 17A (IL-17A) is considered an important component in host defense against Candida infections and is modulated by Candida-induced impairment of tryptophan-kynurenine metabolism.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Elevated Levels of Interleukin 17A and Kynurenine in Candidemic Patients, Compared With Levels in Noncandidemic Patients in the Intensive Care Unit and Those in Healthy Controls