Open AccessATF3 Confers Resistance to Pneumococcal Infection Through Positive Regulation of Cytokine Production
Author(s) -
Cattien V. Nguyen,
Eunhye Kim,
Truc Thanh Luong,
Suhkneung Pyo,
DongKwon Rhee
Publication year - 2014
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiu352
Subject(s) - biology , streptococcus pneumoniae , pneumolysin , microbiology and biotechnology , immunology , tumor necrosis factor alpha , cytokine , innate immune system , pneumococcal pneumonia , immune system , antibiotics
Activating transcription factor-3 (ATF3) is known as a suppressor of cytokine production after exposure to lipopolysaccharide or during gram-negative bacterial infection. However, the mechanism by which ATF3 regulates innate immunity against gram-positive bacterial infection, particularly Streptococcus pneumoniae, remains unknown.