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Schistosomes infect 200 million individuals annually and cause significant hepatic fibrosis in up to 20%. Little is known regarding the mechanisms of schistosome-associated hepatic fibrosis in humans, and few biomarkers for risk of fibrosis have been identified.

Tissue Inhibitor of Matrix-Metalloprotease–1 Predicts Risk of Hepatic Fibrosis in Human Schistosoma japonicum Infection