English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Evidence is scant on long-term implications of body mass index (BMI) gains over the life-course for poor physical functioning (PF). Using the 1958 British birth cohort (N=8,674) we examine whether i) birthweight and BMI across the life-course; ii) BMI gains at specific life-stages; and iii) age of obesity onset, were associated with PF at 50y. At each adult age, obesity was associated with poor PF (e.g. for males at 23y adjusted-ORs for poor PF was 2.28(1.34,3.91)). BMI gains were associated with poor PF (e.g. for females, adjusted-OR per SD BMI gain 16-23y was 1.28(1.13,1.46)). Longer obesity duration was associated with poor PF (e.g. for males, adjusted-OR was 2.32(1.26,4.29) for childhood obesity onset, and 1.50(1.16,1.96) for mid-adulthood onset); associations were abolished with further adjustment for 50y BMI. Obesity, BMI gains, and earlier obesity onset were associated with poor PF in mid-adulthood reinforcing the importance of preventing obesity early in the lifecourse.

BIRTHWEIGHT, LIFETIME OBESITY, AND PHYSICAL FUNCTIONING IN MID-ADULTHOOD: A NATIONWIDE BIRTH COHORT STUDY