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The panellist Mark Kroese will discuss about the opportunities and current challenges for the use of polygenic risk scores in risk prediction and the prevention of common adult onset conditions. Considerable progress has been made in the scientific development of polygenic risk scores for use in estimating the risk of common chronic conditions. However, key challenges remain in developing practical applications for their use in the clinic and establishing the evidence of their clinical utility. Questions remain about how such approaches will improve current risk prediction tools and methods. In addition, there is much debate about the nature of the possible benefits of using such scores for clinical advice and decision making as well as the likely impact on individual behaviour and future outcomes. Do we need a different approach in developing future risk prediction tools?

Opportunities and current challenges for the use of polygenic risk scores in risk prediction and prevention