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Funding Acknowledgements Type of funding sources: None. Objectives To determine the gender differences in the effect of sleep disorders on risk of myocardial infarction (MI) and stroke in population 25-64 years over 16 years of follow-up. Methods Under the third screening of WHO program MONICA -Psychosocial a random representative sample of both gender aged 25- 64 years in Novosibirsk was examined in 1994 (n = 1346, male 48.8%, mean age 44,9 ± 0,4 years). The sleep assessment was performed using the Jenkins Sleep Questionnaire. There were 15 cases of new-onset MI in women and 30 in men, new-onset stroke 35 cases in women and 22 in men from 1994 to 2010. Results In an open population aged 25-64 years 48.6% of men and 65.9% of women had sleep disorders (p&amp;lt; 0.001). Univariate analysis showed 2.4-fold risk of MI in those males with SD over 16-year of follow-up (95%CI 1.1-5.3; p&amp;lt; 0.05) but not for women. MI risk was higher in those men who were never married, divorced or widowed (p for all &amp;lt;0.01) compared to married ones. Risk of stroke was higher in men HR = 3 (95%CI 1.2-7.6;p &amp;lt; 0.05) than in women HR = 1.9 (95%CI 1.03-3.7; p &amp;lt; 0.05). Multivariate analysis revealed 2.8-fold risk of stroke (95%CI 1.1-7.1; p &amp;lt; 0.05) in men and HR = 2.7 in women (95%CI 1.4-5.42;p &amp;lt; 0.01) with SD. Stroke risk was higher in men with lower educational level and in women with college degree in those with SD. Conclusions Sleep disorders is a risk factor of MI in men only and stroke for both gender and negative social gradient increases cardiovascular risk.

european journal of preventive cardiology

Gender differences in risk of myocardial infarction and stroke in population with sleep disorders in Russia / Siberia: population-based study MONICA-psychosocial