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Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality in worldwide population.1 Patients admitted to Emergency Care Unit and/or Intensive Coronary Care Unit remain at high risk of recurrent events, hospitalization, and cardiovascular death.1 In last decades, diabetic mellitus (DM) affected patients have been diagnosed as one of four patients with AMI.2 New randomized controlled trials have investigated pharmacologic and non-pharmacologic management strategies to reduce all-cause mortality for patients with diabetes and AMI. In fact, the International American and European guidelines1,2 have reported evidence-based recommendations for treating AMI and DM. Parallel to an innovative and broader use of anti-ischaemic and anti-remodelling drugs to treat AMI, the primary angioplasty [primary percoutaneous coronary intervention (pPCI)] therapeutical development has drastically reduced the mortality in affected patients.1 The not discussable percutaneous coronary intervention (PCI) impact in AMI patients prognosis is not so great as expected in DM patients.3 Moreover, we have to consider DM patients, as a population of patients with different clinical characteristics, that render more difficult the best clinical pharmacological and non-pharmacological treatment (pPCI) to reduce worse prognosis during AMI. For these reasons, we have to improve current clinical diagnosis and treatment, and planning future strategies for DM affected by AMI.In the current study,4 Singh and co-workers evidenced that ‘despite rapid revascularization and treatment of hyperglycaemia, patients with acute hyperglycaemia (AH) continue to have …

Glycemic control and acute coronary syndrome: the debate continues