English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Institute of Cardiology, Kyiv, Ukraine The role of lymphocytes in  the progression of atherosclerosis is still unclear. T-cells helper (CD4+) and suppressor (CD8+) subtypes are activated in acute cardiac injury and myocardial infarction (AMI),including cytotoxicity mediated by CD8+ T-cells and immunoregulatory activity mediated by CD4+ T-cells (which can also enhance the CD8+ T-cell cytotoxicity). The natural killer (NK) cells are important in the infarcted myocardium, where it affects heart remodeling. The aim of the study was to identify the difference in the dynamic profile of T-cells (CD4 +, CD8 +) and NK cells (CD16 / 56+) in STEMI patients with and without complications during 1-year follow-up. Methods The composition of individual subtypes of T-cells (CD4 +, CD8 +) and NK cells (CD16 / 56+) in the venous blood was evaluated retrospectively in 60 pts with STEMI, treated with primary PCI, at admission and on day 7. The following cardiovascular events were considered as the end point in remote (1 year) observation: death, AMI, stroke, revascularization, development/decompensation of heart failure and cardiac ischemia. All patients were divided into 2 groups depending on the presence (1st group - 35 pts) and absence of endpoint (2nd group - 25 pts). Both groups were comparable by the clinical profile. Results: There were lower number of T-suppressor on day 7 in patients with cardiovascular events during long-term follow-up (357.4 ± 36.2 /μl in group 1 vs 779.7 ± 222.8 /μl in group 2, p &amp;lt;0,01) with the trend in their percentage (23.6 ± 1.5% vs. 27.6 ± 2.3% in group 2, p &amp;lt;0.1). In pts with poor prognosis NK cells number and percentage has tendency to increase at the admission– 45,6% vs 37,3% in the group 2. Tab 1 Conclusion We can assume that the initial tendency to increase in the number and percentage of NK cells (CD16 / 56 +) followed by a decrease in the number and percentage of T cells suppressor (CD8+) on STEMI day 7 are associates with an undesirable 1-year prognosis. Dynamics of T-cells subtypes in STEMI pGroup 1 (n = 35)Group 2 (n = 25)Р group 1 vs group 2Day1Day 7Day 1Day7T-cells suppressor (CD8+) %20,9 ± 1,623,6 ± 1,524,2 ± 2,127,6 ± 2,3&amp;lt;0.1 on day 7T-cells suppressor (CD8+) /μl341,4 ± 40,1357,4 ± 36,2338,4 ± 46,8779,7 ± 222,8&amp;lt;0.02 on day 7T-cells helper (CD4+) %42,0 ± 1,948,0 ± 1,345,3 ± 2,248,0 ± 2,1&amp;gt;0.1T-cells helper (CD8+) /μl671,9 ± 72,9771,7 ± 68,0666,6 ± 94,2900,9 ± 115,8&amp;gt;0.1Natural killer (CD16 / 56+) %18,4 ± 1,912,5 ± 1,413,4 ± 2,09,73 ± 0,96&amp;lt;0.1 on day 1Natural killer (CD16 / 56+) /μl263,7 ± 31,9219,7 ± 33,8181,1 ± 26,7170,6 ± 25,9&amp;lt;0.1 on day 1

The profile of T-cells (CD4 +, CD8 +) and natural killer cells (CD16 / 56+) in STEMI patients with poor prognosis