Identification and characterization of two ankyrin-B isoforms in mammalian heart | Zendy

Henry C. Wu | Zendy; Gokay Yamankurt | Zendy; Jialie Luo | Zendy; Janani Subramaniam | Zendy; S. Shahrukh Hashmi | Zendy; Hongzhen Hu | Zendy; Shane R. Cunha | Zendy

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Identification and characterization of two ankyrin-B isoforms in mammalian heart

Author(s) -

Henry C. Wu,

Gokay Yamankurt,

Jialie Luo,

Janani Subramaniam,

S. Shahrukh Hashmi,

Hongzhen Hu,

Shane R. Cunha

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv184

Subject(s) - ankyrin , gene isoform , microbiology and biotechnology , gene knockdown , ankyrin repeat , biology , alternative splicing , gene , biochemistry

Excitation-contraction coupling in cardiomyocytes requires the proper targeting and retention of membrane proteins to unique domains by adaptor proteins like ankyrin-B. While ankyrin-B has been shown to interact with a variety of membrane and structural proteins located at different subcellular domains in cardiomyocytes, what regulates the specificity of ankyrin-B for particular interacting proteins remains elusive.

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