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The traditional view is that low shear stress of blood flow acceleratesatherosclerosis. How does a low shear stress damage the vessel or aggravateatherosclerosis? It is a puzzling question. Furthermore, shear stress of veinsis similar to that of Relatively Vulnerable Zones (RVZ) of arteries, whileintimal thickening of veins is not obvious as the arteries. There are manyplaces in arterioles with lower shear stress as the decrease of blood velocity,while the thickening of arterioles is not as obvious as that of themedium-sized arteries. These issues make it unconvincing for us to explainatherogenesis with lower shear stress. According to Bernoulli fluid equation(P+1/2\r{ho}v^2+\r{ho}gh=constant), in a closed pipe full of flowing blood, atthe same height, the hydrostatic pressure is inversely proportional to thesecond power of blood velocity. At any point of per unit mass of fluid microcluster here, the reduction of 1/2\r{ho}v^2 would be converted into P.Therefore, hydrostatic pressure(P) is inversely proportional to v^2 in a veryshort distance or in the same transection of the artery. When blood microcluster flows over a very short distance or the same transection of the artery,previous studies did not consider the conversion between 1/2\r{ho}v^2 and P.Therefore, low shear stress aggravates atherosclerosis is an appearance, andthe essence is that these areas with smaller blood velocity have much biggerhydrostatic pressure, which aggravates atherosclerosis. This perfectly explainsthe predisposing sites of atherosclerosis.

Hemodynamic Bigger Hydrostatic Pressure Instead of Lower Shear Stress Aggravates Atherosclerosis