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Thrombosis is a major global disease burden with almost 60% of cases related to underlying heredity and most cases still idiopathic. Synonymous single nucleotide polymorphisms (sSNPs) are considered silent and phenotypically neutral. Our previous study revealed a novel synonymous FII c.1824C&gt;T variant as a potential risk factor for pregnancy loss, but it has not yet been associated with thrombotic diseases.

clinical chemistry

The Silence Speaks, but We Do Not Listen: Synonymous c.1824C&amp;gt;T Gene Variant in the Last Exon of the Prothrombin Gene as a New Prothrombotic Risk Factor