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Neural tube defects (NTDs) are the most common severe congenital malformations that occur as a result of failure of neural tube closure at the beginning of pregnancy (24–28 days after conception). Genetic (4)(2)(3), environmental (4), and nutritional factors (5)(6)(7)(8)(9) can be involved in the etiology of NTDs.Among the nutritional deficiencies, maternal folate status during pregnancy is considered one of the most important risk factors for NTDs, leading to a recommended dietary folate allowance for pregnant women (600 μg/day) from supplements and fortified food (10).Folate is a cofactor in several enzymatic reactions in the formation of new tissues. Low maternal red cell folate (RCF) and serum folate concentrations have been strongly associated with the occurrence of NTDs (8)(9), and maternal RCF concentrations in particular have been shown to correlate with the occurrence of NTDs in a concentration-dependent fashion (5). However, some case-control studies did not show lower mean folate concentrations in pregnant women carrying fetuses with NTDs (6)(7)(9).The differences among the cited studies may have been attributable to intrinsic differences in the methods used for folate determination. Currently, the major analytical approaches used for folate determination are microbiological assays, radioassays, chemiluminescence assays, HPLC, and ion-capture assays.The aim of the present study was to compare serum folate results obtained by two automated folate tests in 55 pregnant women carrying unaffected fetuses or fetuses …

Serum Folate by Two Methods in Pregnant Women Carrying Fetuses with Neural Tube Defects