English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Mass spectrometry coupled with gas chromatography (GC/MS) is a powerful analytical tool combining analytical sensitivity and specificity. Its successful application to toxicology and in-born error testing is well known. In the current healthcare environment, clinical laboratories must identify means to reduce costs and improve productivity, including workstation consolidation (1) . This applies equally well to the utilization of specialized tools such as GC/MS, and the ability to maximize the productivity of a GC/MS set-up should enhance its economic value to the laboratory.We have had in use in our laboratory a GC/MS method for the measurement of methylmalonic acid (MMA) in plasma, based on solid phase anion-exchange extraction, derivatization with cyclohexanol, and separation with quantification using GC/MS (2) . Gabapentin (Neurontin) is a relatively new antiepileptic drug with a structure similar to the neurotransmitter γ-aminobutyric acid but containing a 6-carbon ring in place of the central methylene group of γ-aminobutyric acid (3)(4)(5) . Efficacy studies have reported patient serum gabapentin concentrations of 0.5–10.0 mg/L (3) . Gabapentin concentrations in serum have been measured using HPLC, gas chromatography, and capillary electrophoresis (6)(7)(8)(9) . Because both gabapentin and MMA are relatively small molecular weight organic acids, …

Cost-efficient Use of Gas Chromatography–Mass Spectrometry: A “Piggyback” Method for Analysis of Gabapentin