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Thiocyanate is an end product of detoxification of hydrogen cyanide present in cigarette smoke. Its excretion in urine, saliva, and sweat can thus provide a useful marker of exposure in smokers and nonsmokers (1)(2)(3)(4). Salivary tests have the advantages of easy, noninvasive sampling and of good stability, even in nondemanding storage conditions (5). However, thiocyanate and other cyanogens are also found in many foods including cabbage, broccoli, almond, and horseradish. Consequently, their ingestion can be supposed to artifactually increase thiocyanate excretion, thereby affecting the specificity of the test (6).To evaluate the importance of this alimentary source of thiocyanate, we selected 65 subjects from the screening of 221 consecutive subjects in a smoking cessation program and from a healthy population of adult volunteers. Ages ranged from 18 to 72 years (median 48 years). All subjects were asked to fill in a questionnaire on their smoking habits …

Specificity of Salivary Thiocyanate as Marker of Cigarette Smoking Is Not Affected by Alimentary Sources