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Hydrogen sulfide (H 2 S) is an important endogenous gaseous transmitter in many physiological functions. Plasma H 2 S decreased, and angiotensin II (Ang II) type 1 receptor (AT1R) increased in the myocardial tissues in 2-kidney 1-clip (2K1C) rats than in normotensive rats. Accumulating evidences suggest that H 2 S inhibited Ang II/AT1R pathway to regulate cardiovascular function. Therefore, we hypothesized that H 2 S may exert beneficial effects on myocardial remodeling in 2K1C rat models of renovascular hypertension.

Hydrogen Sulfide Improves Myocardial RemodelingviaDownregulated Angiotensin Ⅱ/AT1R Pathway in Renovascular Hypertensive Rats