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The results show that spatial localization of desmosomes in polarized epithelial cells is jointly regulated by polarity protein Par3 and desmosomal protein Pkp3. This process is apparently based on the Par3-dependent interplay between two pools of Pkp3 that are located in different cell compartments.

Plakophilin 3 and Par3 facilitate desmosomes’ association with the apical junctional complex