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GNL1 inhibits cell apoptosis and promotes cell growth by inducing cytoplasmic retention and stabilization of p21 through AKT-mediated phosphorylation. Our data elucidate a novel GNL1/AKT/p21 signaling cascade to provide a growth benefit to cancer cells and this may be an ideal target for cancer therapeutic intervention.

Guanine nucleotide binding protein like-1 (GNL1) promotes cancer cell proliferation and survival through AKT/p21 CIP1 signaling cascade

Guanine nucleotide binding protein like-1 (GNL1) promotes cancer cell proliferation and survival through AKT/p21 ^CIP1 signaling cascade