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High-throughput efforts of the past decade have afforded us with the first impressions of how the whole genome actually changes in a patient’s cancer. Computational approaches are playing an integral role in tackling this flood of information, but it has also become clear that cancer will not be solved by improving p values, just like a Manhattan murder mystery will not be solved by going through the phone book.

Calling on the cancer sleuths: how cell biologists will do the detective legwork of the postcancer genome era