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Integrin α v β 3 is a molecular marker for the estimation of tumor angiogenesis. 99m Tc-IDA-D-[c(RGDfK)] 2 (also known as BIK-505) is a recently developed radiotracer for single-photon emission computed tomography, with good affinity for integrin α v β 3 . In this study, the authors investigated the whole-body distribution and internal radiation dosimetry of 99m Tc-IDA-D-[c(RGDfK)] 2 in elderly human participants.

cancer biotherapy and radiopharmaceuticals

Biodistribution and Internal Radiation Dosimetry of 99mTc-IDA-D-[c(RGDfK)]2 (BIK-505), a Novel SPECT Radiotracer for the Imaging of Integrin αvβ3 Expression