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Theoretical physics is the search for simple and universal mathematicaldescriptions of the natural world. In contrast, much of modern biology is anexploration of the complexity and diversity of life. For many, this contrast isprima facie evidence that theory, in the sense that physicists use the word, isimpossible in a biological context. For others, this contrast serves tohighlight a grand challenge. I'm an optimist, and believe (along with manycolleagues) that the time is ripe for the emergence of a more unifiedtheoretical physics of biological systems, building on successes in thinkingabout particular phenomena. In this essay I try to explain the reasons for myoptimism, through a combination of historical and modern examples.

Perspectives on theory at the interface of physics and biology