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Aptamers are chemically produced oligonucleotides, able to bind a variety oftargets such as drugs, proteins and pathogens with high sensitivity andselectivity. Therefore, aptamers are largely employed for producing label-freebiosensors, with significant applications in diagnostics and drug delivery. Inparticular, the anti-thrombin aptamers are biomolecules of high interest forclinical use, because of their ability to recognize and bind the thrombinenzyme. Among them, the DNA 15-mer thrombin-binding aptamer (TBA), has beenwidely explored concerning both its structure, which was resolved withdifferent techniques, and its function, especially about the possibility ofusing it as the active part of biosensors. This paper proposes a microscopicmodel of the electrical properties of TBA and the aptamer-thrombin complex,combining information from both structure and function. The novelty consists indescribing both the aptamer alone and the complex as an impedance network, thusgoing deeper inside the issues addressed in an emerging electronics branchknown as proteotronics. The theoretical results are compared and validated withElectrochemical Impedance Spectroscopy measurements reported in the literature.Finally, the model suggests resistance measurements as a novel tool for testingaptamer-target affinity.

Modeling the microscopic electrical properties of thrombin binding aptamer (TBA) for label-free biosensors