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This paper presents experimental results about transport of dilutesuspensions of nano-objects in silicon-glass micrometric and sub-micrometricchannels. Two kinds of objects are used: solid, rigid latex beads and sphericalcapsule-shaped, soft polymersomes. They are tracked using fluorescencemicroscopy. Three parameters are studied: confinement (ratio between particlediameter and channel depth), Brownian diffusion and particle nature. The aim ofthis work is to understand how these different parameters affect the transportof suspensions in narrow channels and to understand the different mechanisms atplay. Concerning the solid beads we observe the appearance of two regimes, onewhere the experimental mean velocity is close to the expected one and anotherwhere this velocity is lower. This is directly related to a competition betweenconfinement, Brownian diffusion and advection. These two regimes are shown tobe linked to the homogeneity of particles distribution in the channel depth,which we experimentally deduce from velocity distributions. This inhomogeneityappears during the entrance process into the sub-micrometric channels, as forhydrodynamic separation or deterministic lateral displacement. Concerning thenature of the particles we observed a shift of transition towards the secondregime likely due to the relationships between shear stress and polymersomesmechanical properties which could reduce the inhomogeneity imposed by thegeometry of our device.

Transport of nano-objects in narrow channels: influence of Brownian diffusion, confinement and particle nature