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Barros and Austin (1) have reported on the inhibition of ovulation in the golden hamster by parenteral actinomycin D (AMD). During studies aimed at characterising the meiotic chromosome damage induced by various inhibitors of DNA, RNA, and protein, the author has made some observations in vitro and in vivo on the effects of AMD on female mouse meiosis . These data extend the information of Barros and Austin (1) on hamster and of Pool and Lipner (2) on rabbit, particularly with reference to cytogenetic changes in the inhibited eggs .

MEIOSIS AND INHIBITION OF OVULATION IN MOUSE EGGS TREATED WITH ACTINOMYCIN D