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This systematic review shows the effectiveness of  Matricaria chamomilla  for improving health. Original papers and case reports published during 2014–2018 in PubMed, Science Direct and Scopus were included. Most studies were  in vitro , performed with extracts, in 2018, and originated from Iran.  In vitro  assays focused mainly on antimicrobial, antiparasitic and antioxidant activities.  In vivo  studies specially investigated organ and tissue protective activity of chamomile. Clinical trials have validated some of these  in vitro  and  in vivo  pharmacological activities (diabetes mellitus, hypertension and pain). Future preclinical and clinical investigations should be aimed at deeping into pure compounds responsible for activities.

The pharmacology and clinical efficacy of matricaria recutita L.: a systematic review of in vitro, in vivo studies and clinical trials