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In the United States (US), morbidity and mortality from pediatric asthma are increasing. We explored racial inequities using the Multiple Causes of Death Files of the US National Center for Health Statistics and the Wide-ranging Online Data for Epidemiologic Research (WONDER) for 1–14-year-olds from 1999 to 2018. We obtained mortality rates, Black:White mortality rate ratios (MRRs) and Annual Percent Change (APC). We tested for significance with 95% confidence intervals and joinpoint regression. Of 2,731 deaths from asthma, Blacks comprised 65.25% and 21.25% of the population. Black:White MRRs were 6.43 for 1–4, 7.54 for 5–9 and 6.88 for 10–14-year-olds of 6.88. The APC decline of −2.56 (p &lt; 0.05) was significant among Whites but not Blacks. MRRs increased significantly from 4.23 in 2000 to16.57 in 2015 and declined to 6.69 in 2018. Among Black boys and girls, mortality rates were highest in Large Central Metropolitan areas. For Whites, rates were similar by urbanization in girls but were highest in Non-core, Non-metropolitan rural areas in boys. These descriptive data demonstrate statistically significant racial inequities in mortality from pediatric asthma in the US. They generate hypotheses, including, but not limited to, those related to under-resourced families and communities as well as economic and social marginalization. These and other plausible hypotheses require direct testing in analytic epidemiologic studies designed a priori to do so. In the meanwhile, efforts are necessary to strengthen community-driven initiatives and focus attention on inequitable systems, hierarchies, social structure and institutional practices. These include multifactorial interventions for individual, environmental and societal risk factors and educational efforts toward health-care providers and their patients about structural racism; these may combat, at least in part, vulnerabilities in US children and youth and improve racial inequities overall and from pediatric asthma.

Racial Inequalities in Mortality from Pediatric Asthma in the United States: Clinical and Public Health Challenges