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One new tirucallane triterpene named as canarimoic acid ( 1 ), and three known analogues: 3 β -hydroxytirucalla-8,24-dien-21-oic acid ( 2 ), 3 α -acetyltirucalla-8,24-diene-21oic acid ( 3 ) and 3-oxotirucalla-8,24-dien-21-oic ( 4 ) were isolated from the hydro-ethanolic crude extract of  Canarium schweinfurthii . Their structures were established by extensive analysis of 1 D and 2 D NMR data in conjunction with mass spectrometry and by comparison with those reported in the literature. The evaluation of their antisalmonellal activity using broth microdilution method showed that compound  3  was the most active (MIC =16 µg/mL) against  Salmonella  Typhi and  Salmonella  Typhimurium followed by compound  1  (MIC= 32 µg/mL) against  Salmonella  Typhi and  Salmonella Enteritidis .

Canarimoic acid: new tirucallane triterpene with antisalmonellal activity from the stem bark of Canarium schweinfurthii Engl.