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Five new secoiridoid glycosides, cornusphenosides E-I ( 1 – 5 ), were isolated and characterized from an active fraction of ethanol extract of the fruits of  Cornus officinalis . Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and HRESIMS experiments. In the preliminary assay, compound  5  (when evaluated at 10  μ M) showed the neuroprotective effect against H 2 O 2 -induced SH-SY5Y cell damage.

Secoiridoid glycosides from the fruits of Cornus officinalis