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Phytochemical investigation of the leaves of  Lepisanthes rubiginosa  led to the isolation of two new glycosides, lepisantheside A ( 1 ) and lepisantheside B ( 2 ), together with two known compounds acutoside A ( 3 ) and 3-O-[ β -D-xylopyranosyl-(1→3)- β -D-glucopyranosyl-]-oleanolic acid ( 4) . Their structures were elucidated by means of spectroscopic methods (HR-ESI-MS, 1D and 2D NMR), and by comparison with the reported data. The cytotoxicity of compounds  1–4  against four human cancer cell lines (KB, HepG2, SK-LU-1 and MCF7) was evaluated. Compound  4  exhibited significant activity with IC 50  values of 9.57, 6.66, 6.97 and 18.32 µM, respectively, in comparison with the postive control ellipticine.

natural product research

Two new glycosides, farnesyl pentaglycoside and oleanane triglycoside from  Lepisanthes rubiginosa , a mangrove plant collected from Thua Thien-Hue province, Vietnam