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Cancer as one of the most common causes of death has always been one of the major health challenges globally. Since, the identification of tumors in the early tumor stages can significantly reduce mortality rates; it is required to introduce novel early detection tumor markers. MicroRNAs (miRNAs) have pivotal roles in regulation of cell proliferation, migration, apoptosis, and tumor progression. Moreover, due to the higher stability of miRNAs than mRNAs in body fluids, they can be considered as non-invasive diagnostic or prognostic markers in cancer patients. In the present review we have summarized the role of miR-217 during tumor progressions. The  miR-217  functions were categorized based on its target molecular mechanisms and signaling pathways. It was observed that  miR-217  mainly exerts its function by regulation of the transcription factors during tumor progressions. The WNT, MAPK, and PI3K/AKT signaling pathways were also important molecular targets of  miR-217  in different cancers. The present review clarifies the molecular biology of  miR-217  and paves the way of introducing miR-217 as a non-invasive diagnostic marker and therapeutic target in cancer therapy.

MicroRNA-217: a therapeutic and diagnostic tumor marker