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Metabolic syndrome (MetS) is a clustering of several physiological alterations. This study was designed to evaluate the effects of MetS on rats spermatogenesis and steroidogenesis. We developed a MetS rodent model using high-sugar and high-fat diet. MetS rats showed severe disorders in sperm parameters. Interestingly, a significant increase in malondialdehyde level and a decrease in the antioxidant activities were observed. Moreover, qRT-PCR analysis showed Bax down-regulation and Bcl-2 up-regulation. A decrease in testosterone level was identified, correlated with the  CYP11A1 ,  CYP17A1  and  17β HSD  testicular marker down-regulation. Finally, MetS rats showed an up-regulation of pro-inflammatory cytokines receptors  IL-1R  and  IL-6R . MetS induced severe testis toxicity in male rats. Mets markedly distorted sperm parameters, inhibited the transcription of steroidogenic enzymes and led to oxidative stress, inflammation, and alteration of Bax/Bcl-2 ratioin testicular tissues.

Spermatogenesis and steroidogenesis disruption in a model of metabolic syndrome rats