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SIRT1  and  HDAC  9 genes are related to inflammation and may contribute to the pathogenesis of coronary artery disease (CAD). We aimed to evaluate the expression level, methylation profile and polymorphisms of these genes in CAD patients. In this study, 50 CAD patients and 50 healthy individuals were recruited. The expression level change was evaluated using the TaqMan Real-Time PCR method. The methylation of genes promoter and genotyping of polymorphisms were evaluated by the HRM. The expression level of  SIRT1  was reduced while the  HDAC9  expression level showed a significant elevation ( p  &lt; .001). The  SIRT1  gene promoter was hypomethylated and the  HDAC9  gene promoter was hypermethylated in CAD patients. Also, CG + GG genotype in  SIRT1  and both genotypes in the  HDAC9  gene were associated with expression change. SIRT1  and  HDAC9  genes, expression changes can be suggested as a potential biomarker for CAD detection.

Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease