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Objective:  This study investigated effect of zaprinast and avanafil on vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP) 4 and 7, and vitamin D 3  levels against the negative effect of dexamethazone. Method:  Rats were randomly divided into four groups ( n  = 6). Control: Empty a syringe was immersed and removed subcutaneously. Dexamethasone (DEX): 120 µg/kg DEX was injected subcutaneously once a day for 28 days. DEX + zaprinast and DEX + avanafil groups: 10 mg/kg zaprinast and avanafil were administrated to rats in addition to the same procedure in the DEX, respectively. VitaminD 3 , VEGF, BMP4 and 7 levels by enzyme linked immunosorbent assay (ELISA) and angiogenesis by histopathological/immunohistochemical were evaluated. Results:  BMP4 values in the DEX were lower than the other groups ( p  &lt; .05). DEX + zaprinast and DEX + avanafil exhibited an increase in all the parameters compared to the control and DEX ( p  &lt; .05). However, these were not significant for the DEX + zaprinast ( p  &gt; .05). Also, there was a significant increase in angiogenesis in the DEX + zaprinast and DEX + avanafil. Conclusion:  Zaprinast and significantly avanafil induced vitamin D 3 , BMP4 and 7 levels by increasing angiogenesis in renal.

archives of physiology and biochemistry

Zaprinast and avanafil increase the vascular endothelial growth factor, vitamin D 3 , bone morphogenic proteins 4 and 7 levels in the kidney tissue of male rats applied the glucocorticoid