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We speculated impacts of BM-MSCs and UC-EPCs on reversal of hepatic injury induced by carbon tetrachloride (CCl4). Fifty adult rats were divided into five groups: control group, CCl4A group, CCl4B group, CCl4/BM-MSCs group and CCl4/UC-EPCs group. Blood samples were driven to measure concentration of albumin and ALT. Quantitative expression of HGF, TGF-β, MMP-2, and VEGF were assessed by PCR. Histological and immunohistochemistry examination of the liver tissue were performed. There was elevating albumin ( p  &lt; .05) and reducing ALT ( p  &lt; .05) concentrations in groups treated with BM-MSCs and UC-EPCs compared to untreated CCL4A&amp;B groups. UC-EPCs treated group have significantly higher MMP-2 and VEGF ( p  &lt; .01) genes expression than BM-MSCs treated group. Furthermore, UC-EPCs were more valuable than BMMSCs in increasing gene expression of HGF ( p  &lt; .05) and immunohistochemistry of α-SMA and Ki-67 ( p  &lt; .01). BM-MSCs have significantly lower TGF-β ( p  &lt; .00) compared to UC-EPCs. This study highlighted on liver regeneration role of both UC-EPCs and BM-MSCs in liver fibrosis.

Comparative study on effect of mesenchymal stem cells and endothelial progenitor cells on treatment of experimental CCL4-induced liver fibrosis