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The present study aimed to investigate the effects of  Juglans regia  (JR) extract on hyperglycaemia and insulin sensitivity. Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes +  Juglans regia  (D + JR) and Diabetes + Metformin (D + M). In the D + JR group, Fasting blood glucose (FBG) levels decreased from day 14 onwards. There was a significant decrease in plasma levels of Fibronectin Type III Domain Containing 5 (FNDC5) and adiponectin (ADP) in the DC group compared to the C group ( p  &lt; .01,  p  &lt; .001 respectively). In the D + JR group, there was a significant increase in plasma FNDC5 and ADP ( p  &lt; .05), while the plasma Tumour necrosis factor-alpha (TNF-α) levels were decreased compared to the DC group ( p  &lt; .001). In conclusion, the present study found that JR and its bioactive components alleviated insulin resistance by increasing ADP and FNDC5 and decreasing FBG in a rat model of streptozotocin (STZ) + nicotinamide (NAD)-induced type 2 diabetes (T2D).HighlightsJuglans regia  extract increased insulin sensitivity.Juglans regia  extract significantly reduced the level of fasting blood glucose.Juglans regia  extract reduced TNF-α levels in rats with type 2 diabetes.Juglans regia  extract prevent weight loss in type 2 diabetes. Juglans regia  extract increased insulin sensitivity. Juglans regia  extract significantly reduced the level of fasting blood glucose. Juglans regia  extract reduced TNF-α levels in rats with type 2 diabetes. Juglans regia  extract prevent weight loss in type 2 diabetes.

Evaluating the effects of Juglans regia L. extract on hyperglycaemia and insulin sensitivity in experimental type 2 diabetes in rat