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To investigate the effect of laparoscopic surgery in colorectal cancer (CRC) patients with natural orifice specimen extraction (NOSE) on the recovery and quality of life (QOL) of patients. Ninety-two eligible patients were randomly assigned into two groups: the traditional laparoscopy group (L group,  n  = 46) and the laparoscopic transanal specimen extraction group (NL group,  n  = 46). General data, surgery-related indicators, postoperative recovery, and prognosis were compared and analyzed between the two groups. A total of 46 patients in each group were enrolled in this study. The general data and surgery-related indicators were comparable between the two groups (all  p &gt;  .05). There were no significant differences in the time of first flatus, bleeding, obstruction, constipation, and infectious complications between the two groups (all  p &gt;  .05). The differences in the incidence of postoperative diarrhea, pain degree, and satisfaction on the aesthetics of the abdominal wall showed significant differences (χ 2  = 6.133,  p =  .013; χ 2  = 12.116,  p =  .017; χ 2  = 13.463,  p =  .004). The postoperative follow-up time was 3–53 months. There were no significant differences in the postoperative hospital stay, medical costs, hospital readmission rate, incidence of incisional hernia, overall survival, disease-free survival, and QOL between the two groups (all  p &gt;  .05). Conclusion: Laparoscopic surgery with NOSE for eligible patients with CRC was a feasible choice.

Effect of laparoscopic surgery for colorectal cancer with N. O. S. E. on recovery and prognosis of patients