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Investigate how hypertension during pregnancy (HDP) and depression during pregnancy (DDP) independently and jointly affect infant birth outcomes. This population-based, retrospective cohort study included a sample of 68,052 women who participated in PRAMS 2016–2018 survey. Poisson regression was used for adjusted relative risks (aRRs). Compared to women without HDP and DDP, aRRs for PTB and LBW among women with both HDP and DDP are 2.04 (95% CI 1.73, 2.42) and 2.84 (95% CI 2.27, 3.56), respectively, albeit lower than the expected joint effect of risk. DDP may modify the association between HDP and PTB, LBW.

The moderating role of depression in the association between hypertension during pregnancy and birth outcomes