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Origanum onites  L. ( O. onites ) is one of the cultivated  Origanum  species in Turkey. The aim of this study was to determine the cytotoxicity and cellular antioxidant effects of  O. onites  essential oil, carvacrol and  p- cymene on HCT116 and HepG2 cells.  O. onites  essential oil components were analyzed by GC/MS and GC/FID. Cytotoxicity was analyzed via the MTT assay in HCT116 and HepG2 cells. Cellular antioxidant activities of  O. onites  essential oil, carvacrol and  p -cymene were determined with DCFH-DA method. GC/MS analysis identified carvacrol (%78.4) as the main constituent of  O. onites  essential oil. 400 µg/ml concentration of  O. onites  essential oil, carvacrol and  p -cymene were found to be active against HCT116 and HepG2 cells. Also, carvacrol showed higher cellular antioxidant activity than  O. onites  essential oil and  p- cymene. We conclude that  O. onites  essential oil and carvacrol may be a candidate for pharmaceutical products in treatment of cancer.

journal of essential oil research

Cytotoxic activity and antioxidant effects of  Origanum onites  essential oil and its two major contents, carvacrol and  p -cymene on human colorectal (HCT116) and hepatocelluler carcinoma (HepG2) cell lines