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The simple and effective one-pot, three-component protocol for the synthesis of dihydropyrido[2,3- d ]pyrimidine derivatives is presented using a 2-aminoethanesulfonic acid in water. Uracil annulated heterocycles were obtained using various aromatic/aliphatic aldehydes, 6-amino-1,3-dimethyl uracil, and acetyl acetone at 60–80 °C in 2-aminoethanesulfonic acid and water as a green reaction medium. The product obtained was in good to excellent yield (90-94%) in minimum reaction time. Operational simplicity, easy workup, Superior green credentials and the catalyst could be recovered and reused for four consecutive cycles without appreciable loss in catalytic activity.

polycyclic aromatic compounds

An Organocatalytic Newer Synthetic Approach toward the Access of Dihydropyrido[2,3- d ] Pyrimidine in Water: A Perfect Synergy for Eco-compatible Organic Synthesis